https://scholars.lib.ntu.edu.tw/handle/123456789/626916
標題: | Taiwan Expert Consensus Recommendations for Switching to Aripiprazole Long-Acting Once-Monthly in Patients with Schizophrenia | 作者: | Liang, Chih-Sung Su, Tung-Ping MING-HSIEN HSIEH Lee, Chau-Shoun Kuo, Joseph Chiu, Nan-Ying Chen, Po-See Yen, Yung-Chieh Bai, Ya-Mei |
關鍵字: | aripiprazole; atypical antipsychotic; expert consensus; guidance; long-acting injectable antipsychotic; recommendation; schizophrenia | 公開日期: | 13-十一月-2021 | 出版社: | MDPI | 卷: | 11 | 期: | 11 | 來源出版物: | Journal of personalized medicine | 摘要: | In the last decade, long-acting injectable antipsychotics has been widely used in schizophrenia. Aripiprazole long-acting once-monthly (AOM) is the only long-acting dopamine partial agonist antipsychotic approved for schizophrenia; however, a literature search revealed no guidance on safely switching from oral and long-acting injectable antipsychotics to AOM. This study aimed to develop recommendations of AOM use based on existing data and expert consensus. A committee of 30 experts in psychopharmacology from major hospitals across Taiwan was invited. A modified Delphi method was conducted, consisting of two rounds of questionnaires, literature review, three rounds of face-to-face discussion meeting, and two rounds of anonymous voting. The consensus recommendations were developed based on existing data, clinical experiences, and consensus opinions, with 80% agreement among panel members required for final adoption. The panel developed nine consensus statements of switching to AOM for both acute and stable schizophrenia patients receiving oral or long-acting injectable atypical antipsychotics. Recommendations regarding dose adjustment of oral medication and pregnancy/breastfeeding were also included. The nine consensus recommendations provide a guidance on safely switching to AOM. Substantial gaps in knowledge, and more research is necessary. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626916 | ISSN: | 2075-4426 | DOI: | 10.3390/jpm11111198 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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