https://scholars.lib.ntu.edu.tw/handle/123456789/626951
標題: | A High Circulating Tumor Cell Count in Portal Vein Predicts Liver Metastasis From Periampullary or Pancreatic Cancer: A High Portal Venous CTC Count Predicts Liver Metastases | 作者: | YU-WEN TIEN Kuo, Hsun-Chuan Ho, Be-Ing MING-CHU CHANG YU-TING CHANG MEI-FANG CHENG Chen, Huai-Lu Liang, Ting-Yung Wang, Chien-Fang Huang, Chia-Yi Shew, Jin-Yuh Chang, Ying Chih Lee, Eva Yhp Lee, Wen-Hwa |
關鍵字: | BLOOD | 公開日期: | 四月-2016 | 出版社: | LIPPINCOTT WILLIAMS & WILKINS | 卷: | 95 | 期: | 16 | 來源出版物: | Medicine | 摘要: | Circulating tumor cells (CTCs) released from a periampullary or pancreatic cancer can be more frequently detected in the portal than the systemic circulation and potentially can be used to identify patients with liver micrometastases. Aims of this study is to determine if CTCs count in portal venous blood of patients with nonmetastatic periampullary or pancreatic adenocarcinoma can be used as a predictor for subsequent liver metastases. CTCs were quantified in portal and peripheral venous blood samples collected simultaneously during pancreaticoduodenectomy in patients with presumed periampullary or pancreatic adenocarcinoma without image-discernible metastasis. Postoperatively patients were monitored for liver metastasis by abdominal magnetic resonance imaging or computed tomography every 3 months for 1 year. Sixty patients with a pathological diagnosis of periampullary or pancreatic adenocarcinoma were included in the study. Multivariate analysis indicated that portal CTC count was a significant predictor for liver metastases within 6 months after surgery. Eleven of 13 patients with a high portal CTCs count (defined as >112 CMx Platform estimated CTCs in 2 mL blood) developed liver metastases within 6 months after surgery. In contrast, only 6 of 47 patients with a low portal CTC count developed liver metastases (P < 0.0001). A value of 112 CMx Platform estimated CTCs had 64.7% sensitivity and 95.4% specificity to predict liver metastases within 6 months after surgery. We concluded that a high CTC count in portal venous blood collected during pancreaticoduodenectomy in patients with periampullary or pancreatic adenocarcinoma without metastases detected by currently available imaging tools is a significant predictor for liver metastases within 6 months after surgery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626951 | ISSN: | 0025-7974 | DOI: | 10.1097/MD.0000000000003407 |
顯示於: | 醫學系 |
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