https://scholars.lib.ntu.edu.tw/handle/123456789/626953
標題: | A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication | 作者: | Fusco, Dahlene N Brisac, Cynthia John, Sinu P YI-WEN HUANG Chin, Christopher R Xie, Tiao Zhao, Hong Jilg, Nikolaus Zhang, Leiliang Chevaliez, Stephane Wambua, Daniel Lin, Wenyu Peng, Lee Chung, Raymond T Brass, Abraham L |
關鍵字: | Treatment; Gene Regulation; Virology; Mechanism; RAT-LIVER; PATHWAYS; PROTEINS; CELLS; EXPRESSION; COFACTOR; GAMMA | 公開日期: | 六月-2013 | 出版社: | W B SAUNDERS CO-ELSEVIER INC | 卷: | 144 | 期: | 7 | 起(迄)頁: | 1438 | 來源出版物: | Gastroenterology | 摘要: | Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes required for the antiviral function of IFNα (IFN effector genes [IEGs]) are not known. IEGs include not only IFN-stimulated genes, but other nontranscriptionally induced genes that are required for the antiviral effect of IFNα. In contrast to candidate approaches based on analyses of messenger RNA (mRNA) expression, identification of IEGs requires a broad functional approach. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626953 | ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2013.02.026 |
顯示於: | 醫學系 |
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