https://scholars.lib.ntu.edu.tw/handle/123456789/626953
Title: | A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication | Authors: | Fusco, Dahlene N Brisac, Cynthia John, Sinu P YI-WEN HUANG Chin, Christopher R Xie, Tiao Zhao, Hong Jilg, Nikolaus Zhang, Leiliang Chevaliez, Stephane Wambua, Daniel Lin, Wenyu Peng, Lee Chung, Raymond T Brass, Abraham L |
Keywords: | Treatment; Gene Regulation; Virology; Mechanism; RAT-LIVER; PATHWAYS; PROTEINS; CELLS; EXPRESSION; COFACTOR; GAMMA | Issue Date: | Jun-2013 | Publisher: | W B SAUNDERS CO-ELSEVIER INC | Journal Volume: | 144 | Journal Issue: | 7 | Start page/Pages: | 1438 | Source: | Gastroenterology | Abstract: | Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes required for the antiviral function of IFNα (IFN effector genes [IEGs]) are not known. IEGs include not only IFN-stimulated genes, but other nontranscriptionally induced genes that are required for the antiviral effect of IFNα. In contrast to candidate approaches based on analyses of messenger RNA (mRNA) expression, identification of IEGs requires a broad functional approach. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626953 | ISSN: | 0016-5085 | DOI: | 10.1053/j.gastro.2013.02.026 |
Appears in Collections: | 醫學系 |
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