https://scholars.lib.ntu.edu.tw/handle/123456789/627058
標題: | The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells | 作者: | Li, Ju-Pi Lee, Yi-Pang Ma, Jung-Chein Liu, Betty-Revon Hsieh, Nien-Tsu Chen, Dz-Chi CHING-LIANG CHU You, Ren-In |
關鍵字: | FIP-vvo; dendritic cell (DC); fungal immunomodulatory proteins (FIPs) | 公開日期: | 24-五月-2021 | 出版社: | MDPI | 卷: | 11 | 期: | 6 | 來源出版物: | Life | 摘要: | Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine. It contains many nutrients for human health. A fungal immunomodulatory protein (FIP) has been isolated from V. volvacea and named FIP-vvo. Although the regulatory effects of many FIPs on immunity have been identified, the impact of FIP-vvo in modulating dendritic cells (DCs), which play a key role to connect the innate and the adaptive immunity, is not known. In this study, we aim to study the effect of FIP-vvo on the DC maturation and function. We found that FIP-vvo slightly increased the generation of CD11c+ bone marrow-derived DC (BMDC). In addition, the surface expression of MHCII was promoted in BMDCs after the treatment of FIP-vvo, suggesting that FIP-vvo induces DC maturation. Furthermore, FIP-vvo enhanced the ability of BMDCs to activate antigen-specific T cell responses in vitro. In the in vivo study, the FIP-vvo treatment facilitated T cell response in lymph nodes. Therefore, for the first time, our data demonstrated that FIP-vvo promoted DC maturation and function and suggested that FIP-vvo could have benefits for human health by enhancing immunity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627058 | ISSN: | 2075-1729 | DOI: | 10.3390/life11060471 |
顯示於: | 免疫學研究所 |
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