https://scholars.lib.ntu.edu.tw/handle/123456789/627086
標題: | Cerebrospinal fluid soluble programmed death-ligand 1 is a useful prognostic biomarker in primary central nervous system lymphoma | 作者: | Chieh-Lung Cheng CHI-YUAN YAO Huang, Po-Hao CHIH-WEI YU Fang, Wei-Quan Chuang, Wen-Hui SHANG-JU WU YU-JEN LIN Hung, Yu-Chin Tsai, Cheng-Hong SHAN-CHI YU WEN-CHIEN CHOU HWEI-FANG TIEN |
關鍵字: | biomarker; cerebrospinal fluid; primary central nervous system lymphoma; soluble PD-L1; soluble PD-L2 | 公開日期: | 8-十二月-2022 | 出版社: | WILEY | 來源出版物: | British journal of haematology | 摘要: | The increased expression of programmed death-ligands 1 and 2 (PD-L1 and PD-L2, respectively) on tumour cells contributes to immune evasion, suggesting that these proteins are attractive therapeutic targets. This study aimed to evaluate the validity of cerebrospinal fluid (CSF) soluble PD-L1 (sPD-L1) and soluble PD-L2 (sPD-L2) as biomarkers for primary central nervous system lymphoma (PCNSL). We determined the CSF concentrations of sPD-L1 and sPD-L2 in 46 patients with PCNSL using enzyme-linked immunosorbent assays (ELISAs). A control group comprised 153 patients with other brain tumours, inflammatory/infectious status, or neurodegenerative diseases. Only CSF sPD-L1 levels were significantly higher in patients with PCNSL relative to the controls. CSF sPD-L1 also exhibited superior overall discrimination performance compared to CSF sPD-L2 in diagnosing PCNSL. Compared with patients with PCNSL with low CSF sPD-L1 levels, more patients with high levels had high serum lactate dehydrogenase levels, leptomeningeal involvement, and deep-brain involvement. Furthermore, CSF sPD-L1 could predict poor survival in PCNSL but CSF sPD-L2 could not. Intriguingly, CSF sPD-L1 levels were correlated with disease status and their dynamic changes post treatment could predict time to relapse. In conclusion, this study identified CSF sPD-L1 as a promising prognostic biomarker, indicating a therapeutic potential of PD-L1 blockade in PCNSL. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627086 | ISSN: | 0007-1048 | DOI: | 10.1111/bjh.18598 |
顯示於: | 病理學科所 |
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