https://scholars.lib.ntu.edu.tw/handle/123456789/627091
標題: | Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities | 作者: | Fu, Ru-Huei Wang, Yu-Chi Liu, Shih-Ping CHING-LIANG CHU Tsai, Rong-Tzong Ho, Yu-Chen Chang, Wen-Lin Chiu, Shao-Chih Harn, Horng-Jyh Shyu, Woei-Cherng Lin, Shinn-Zong |
關鍵字: | SIGNAL-TRANSDUCTION PATHWAYS; GENE-EXPRESSION; HERBAL MEDICINE; LPS; SURVIVAL; BIOLOGY; ENDOCYTOSIS; INDUCTION; ALKALOIDS; CCR7 | 公開日期: | 2013 | 出版社: | PUBLIC LIBRARY SCIENCE | 卷: | 8 | 期: | 3 | 來源出版物: | PloS ONE | 摘要: | Dendritic cells (DCs) are major modulators in the immune system. One active field of research is the manipulation of DCs as pharmacological targets to screen novel biological modifiers for the treatment of inflammatory and autoimmune disorders. Acetylcorynoline is the major alkaloid component derived from Corydalis bungeana herbs. We assessed the capability of acetylcorynoline to regulate lipopolysaccharide (LPS)-stimulated activation of mouse bone marrow-derived DCs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627091 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0058398 |
顯示於: | 免疫學研究所 |
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