The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells
Journal
iScience
Journal Volume
24
Journal Issue
10
Date Issued
2021
Author(s)
Zhuang X.
Tsukuda S.
Wrensch F.
Wing P.A.C.
Schilling M.
Harris J.M.
Borrmann H.
Morgan S.B.
Cane J.L.
Mailly L.
Thakur N.
Conceicao C.
Sanghani H.
Heydmann L.
Bach C.
Ashton A.
Walsh S.
Tan T.K.
Schimanski L.
Schuster C.
Watashi K.
Hinks T.S.C.
Jagannath A.
Vausdevan S.R.
Bailey D.
Baumert T.F.
McKeating J.A.
Abstract
silencing induced interferon-stimulated gene transcripts in Calu-3 lung epithelial cells, providing a mechanism for the circadian pathway to limit SARS-CoV-2 infection. Our study highlights alternative approaches to understand and improve therapeutic targeting of SARS-CoV-2.
Publisher
Elsevier Inc.
Type
journal article