https://scholars.lib.ntu.edu.tw/handle/123456789/627464
標題: | Protein Glycosylation as Biomarkers in Gynecologic Cancers | 作者: | Shen, Hung Lee, Chia-Yi CHI-HAU CHEN |
關鍵字: | biomarker; cervical cancer; endometrial cancer; glycosylation; ovarian cancer | 公開日期: | 15-十二月-2022 | 出版社: | MDPI | 卷: | 12 | 期: | 12 | 來源出版物: | Diagnostics (Basel, Switzerland) | 摘要: | Gynecologic cancers are the leading cause of death in women. Endometrial, ovarian, and cervical cancer are the three main types of gynecologic cancers. Poor prognoses and high mortality rates of advanced-stage cancer are still challenges of all three types. Diagnostic tools for early cancer detection could be the cornerstone for further cancer treatment and prevention. Glycosylation plays a vital role in cell proliferation, adhesion, motility, and angiogenesis, and is aberrantly expressed in cancer cells. Alterations of glycosylation may represent promising biomarkers with potential diagnostic and monitoring applications, as well as disease prognosis. Many glycosylated biomarkers, including glycoprotein, glycan, and enzyme, were discovered and well-studied for application in gynecologic cancers. Some of them have been developed as targets for cancer treatment. The use of certain biomarkers for diagnostics and monitoring of gynecologic cancers has clinical advantages, as it is quantitative, comparable, convenient, and inexpensive. However, one of the single markers have sufficient sensitivity for the screening of gynecologic cancers. In this review, we introduced the details of glycosylation and the current application of glycosylated biomarkers in these three cancers. Moreover, we also reviewed the different roles of each biomarker in other cancers and aimed to understand these glycosylated biomarkers comprehensively. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627464 | ISSN: | 2075-4418 | DOI: | 10.3390/diagnostics12123177 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。