|Title:||Modelling collateral flow and thrombus permeability during acute ischaemic stroke||Authors:||Padmos, Raymond M
Arrarte Terreros, Nerea
Józsa, Tamás I
Marquering, Henk A
Majoie, Charles B L M
STEPHEN JOHN PAYNE
Hoekstra, Alfons G
|Keywords:||acute ischaemic stroke; blood flow modelling; collateral flow; infarct volume; thrombus permeability||Issue Date:||Oct-2022||Publisher:||ROYAL SOC||Journal Volume:||19||Journal Issue:||195||Source:||Journal of the Royal Society, Interface||Abstract:||
The presence of collaterals and high thrombus permeability are associated with good functional outcomes after an acute ischaemic stroke. We aim to understand the combined effect of the collaterals and thrombus permeability on cerebral blood flow during an acute ischaemic stroke. A cerebral blood flow model including the leptomeningeal collateral circulation is used to simulate cerebral blood flow during an acute ischaemic stroke. The collateral circulation is varied to capture the collateral scores: absent, poor, moderate and good. Measurements of the transit time, void fraction and thrombus length in acute ischaemic stroke patients are used to estimate thrombus permeability. Estimated thrombus permeability ranges between 10-7 and 10-4 mm2. Measured flow rates through the thrombus are small and the effect of a permeable thrombus on brain perfusion during stroke is small compared with the effect of collaterals. Our simulations suggest that the collaterals are a dominant factor in the resulting infarct volume after a stroke.
|Appears in Collections:||應用力學研究所|
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