https://scholars.lib.ntu.edu.tw/handle/123456789/627678
標題: | Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity | 作者: | WEI-SHIUNG YANG Tsou, Pei-Ling Lee, Wei-Jei Tseng, Da-Lun CHI-LING CHEN Peng, Chi-Chung Lee, Kuan-Ching Chen, Mei-Ju Huang, Chang-Jen TONG-YUAN TAI LEE-MING CHUANG |
關鍵字: | obesity; insulin resistance; adiponectin; polymorphism; mRNA; INSULIN-RESISTANCE SYNDROME; ADIPOSE-SPECIFIC PROTEIN; PLASMA-PROTEIN; ASSOCIATION; WEIGHT; SENSITIVITY; MACROPHAGES; ADIPOCYTES; MUTATIONS; PATHWAY | 公開日期: | 七月-2003 | 出版社: | SPRINGER-VERLAG | 卷: | 81 | 期: | 7 | 起(迄)頁: | 428 | 來源出版物: | Journal of molecular medicine (Berlin, Germany) | 摘要: | Adiponectin gene polymorphisms have recently been reported to be associated with obesity, insulin sensitivity, and the risk of type 2 diabetes. We examined a T94G polymorphism of the adiponectin gene in 245 ostensibly normal nondiabetic subjects. The G allele frequency was lower among subjects with higher BMI (> or =27) than in those with lower BMI. BMI was inversely correlated with the dose of G allele. Multivariate linear regression analyses showed that the adiponectin genotypes were significantly related to BMI after adjusting for age and gender. The dose of the G allele was associated with a reduction of approximately 1.12 kg/m(2) in BMI. We further found that the relative mRNA levels of G allele were consistently higher than those of T allele in the omental adipose tissue from 21 heterozygous subjects. Finally, we observed that the expression levels of adiponectin affected insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. In conclusion, the allele-specific differential expression of this common polymorphism could be responsible for its biological effects observed in this and the other studies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627678 | ISSN: | 0946-2716 | DOI: | 10.1007/s00109-002-0409-4 |
顯示於: | 醫學系 |
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