https://scholars.lib.ntu.edu.tw/handle/123456789/627696
Title: | Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci | Authors: | Zubair, Niha Graff, Mariaelisa Luis Ambite, Jose Bush, William S Kichaev, Gleb Lu, Yingchang Manichaikul, Ani Sheu, Wayne H-H Absher, Devin Assimes, Themistocles L Bielinski, Suzette J Bottinger, Erwin P Buzkova, Petra LEE-MING CHUANG Chung, Ren-Hua Cochran, Barbara Dumitrescu, Logan Gottesman, Omri Haessler, Jeffrey W Haiman, Christopher Heiss, Gerardo Hsiung, Chao A Hung, Yi-Jen Hwu, Chii-Min JYH-MING JIMMY JUANG Le Marchand, Loic Lee, I-Te Lee, Wen-Jane Lin, Li-An Lin, Danyu Lin, Shih-Yi Mackey, Rachel H Martin, Lisa W Pasaniuc, Bogdan Peters, Ulrike Predazzi, Irene Quertermous, Thomas Reiner, Alex P Robinson, Jennifer Rotter, Jerome I Ryckman, Kelli K Schreiner, Pamela J Stahl, Eli Tao, Ran Tsai, Michael Y Waite, Lindsay L TZUNG-DAU WANG Buyske, Steven Ida Chen, Yii-Der Cheng, Iona Crawford, Dana C Loos, Ruth J F Rich, Stephen S Fornage, Myriam North, Kari E Kooperberg, Charles Carty, Cara L |
Keywords: | GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; LINKAGE DISEQUILIBRIUM; VARIANTS; METAANALYSIS; TRIGLYCERIDE; ANNOTATION; HAPLOTYPES; TRAITS; RISK | Issue Date: | 15-Dec-2016 | Publisher: | OXFORD UNIV PRESS | Journal Volume: | 25 | Journal Issue: | 24 | Start page/Pages: | 5500 | Source: | Human molecular genetics | Abstract: | Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627696 | ISSN: | 0964-6906 | DOI: | 10.1093/hmg/ddw358 |
Appears in Collections: | 醫學系 |
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