https://scholars.lib.ntu.edu.tw/handle/123456789/627713
標題: | Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients with hypertension, non-insulin-dependent diabetes mellitus, and coronary heart disease in Taiwan | 作者: | LEE-MING CHUANG Chiu, K. C. Chiang, R. T. Lee, K. C. HUEY-PEIR WU Lin, B. J. TONG-YUAN TAI |
公開日期: | 1-一月-1997 | 卷: | 46 | 期: | 10 | 來源出版物: | Metabolism: Clinical and Experimental | 摘要: | An insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene has been identified that determines most of the plasma ACE activity genetically. Association of the D allele with insulin sensitivity and of the D/D genotype with coronary heart disease (CHD) has been reported in various ethnic populations. To study the rote of this genetic polymorphism in patients with hypertension, non-insulin-dependent diabetes mellitus (NIDDM), and NIDDM with CHD in a Taiwanese population, we used a polymerase chain reaction (PCR)-based genotyping technique with an insertion-specific primer for confirmation of the I allele. One hundred ninety-seven unrelated normal controls, 67 subjects with hypertension, 107 subjects with NIDDM, and 70 subjects with NIDDM and CHD were recruited for this study; all were Hen Chinese. Subjects without a history of diabetes were studied by s standard 75-g oral glucose tolerance test. Hypertension was diagnosed according to the Fifth Joint National Committee criteria, and CHD was confirmed by a history of acute myocardial infarction and coronary angiographic intervention. The frequency of the I allele of the ACE gene in the normal population was 64,2%, which was higher then reported in white populations. The prevalence of the I allele of the ACE gene was not significantly increased in subjects with hypertension (73.1%), NIDDM (62.1%), and NIDDM with CHD (65%) compared with healthy controls. The I allele of the ACE gene did not correlate with demographic and metabolic variables. I/D polymorphism of the ACE gene is not a marker for hypertension, NIDDM, or CHD in this Taiwanese population. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627713 | ISSN: | 00260495 | DOI: | 10.1016/S0026-0495(97)90219-5 |
顯示於: | 醫學系 |
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