https://scholars.lib.ntu.edu.tw/handle/123456789/627738
標題: | Screening for the Gly40Ser mutation in the glucagon receptor gene among patients with type 2 diabetes or essential hypertension in Taiwan | 作者: | Huang C.-N. Lee K.-C. HUEY-PEIR WU TONG-YUAN TAI Lin B.-J. LEE-MING CHUANG |
關鍵字: | Essential hypertension | Glucagon receptor gene | PCR- RFLP | Taiwanese | Type 2 diabetes | 公開日期: | 三月-1999 | 卷: | 18 | 期: | 2 | 來源出版物: | Pancreas | 摘要: | As a major counterregulatory hormone of insulin, glucagon plays an important role in regulating glucose homeostasis through its binding to the glucagon receptor. Recently a missense mutation in the glucagon-receptor gene (Gly40Ser) was found to be associated with type 2 diabetes in France and Sardinia, with a frequency as high as 4.6% and 8.3%, respectively. This mutation was also found to be associated with essential hypertension in the white population with a frequency of 5.4%. To investigate the role of this mutation in the pathogenesis of type 2 diabetes and essential hypertension in Taiwanese population, we screened 121 normal controls, 213 unrelated subjects with type 2 diabetes, and 107 unrelated subjects with essential hypertension by use of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). None of the Taiwanese subjects recruited in the study had this receptor mutation. Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627738 | ISSN: | 0885-3177 | DOI: | 10.1097/00006676-199903000-00006 |
顯示於: | 醫學系 |
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