https://scholars.lib.ntu.edu.tw/handle/123456789/627816
標題: | Postoperative cognitive dysfunction in premenopausal versus postmenopausal women | 作者: | Chen, Y-C WEI-ZEN SUN |
關鍵字: | Cognitive function; estrogen; hormone therapy; menopause; postoperative cognitive dysfunction | 公開日期: | 四月-2020 | 出版社: | TAYLOR & FRANCIS LTD | 卷: | 23 | 期: | 2 | 起(迄)頁: | 165 | 來源出版物: | Climacteric : the journal of the International Menopause Society | 摘要: | Purpose: The study examined postoperative cognitive dysfunction in premenopausal and postmenopausal women undergoing surgery with general anesthesia.Methods: This cross-sectional observational study enrolled 30 premenopausal and 28 postmenopausal patients (age 40-60 years) who did not receive hormone replacement therapy, hysterectomy, or oophorectomy. Patients with no menstrual periods for at least 1 year were defined as postmenopausal. The Tablet-based Symbol Digit Modalities Test (T-SDMT) and the Computerized-Digit Vigilance Test (C-DVT) were conducted prior to surgery and on postoperative days (POD) 1 and 7.Results: Postmenopausal patients had a significantly higher T-SDMT reaction time than premenopausal patients preoperatively and on POD 7. Menopausal groups differed in T-SDMT and C-DVT scores preoperatively and postoperatively, but the difference was no longer significant after adjustment for age. Postmenopausal patients had a significantly higher C-DVT hit-reaction time than premenopausal patients on POD 1 and POD 7. On POD 7, 0% of premenopausal and 10.7% of postmenopausal patients had a worse T-SDMT hit-reaction time than at baseline. Pearson's correlation analysis showed that baseline T-SDMT was significantly correlated with age and postmenopausal years; C-DVT was correlated with menopausal duration.Conclusions: By POD 7, menopause status has no noticeable effect on cognitive function in middle-aged women undergoing general surgery. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627816 | ISSN: | 1369-7137 | DOI: | 10.1080/13697137.2019.1653840 |
顯示於: | 醫學系 |
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