https://scholars.lib.ntu.edu.tw/handle/123456789/627953
標題: | Antifungal susceptibility profiles and drug resistance mechanisms of clinical Candida duobushaemulonii isolates from China | 作者: | Chen, Xin-Fei Zhang, Han Jia, Xin-Miao Cao, Jin Li, Li Hu, Xin-Lan Li, Ning Xiao, Yu-Ling Xia, Fei Ye, Li-Yan Hu, Qing-Feng Wu, Xiao-Li Ning, Li-Ping PO-REN HSUEH Fan, Xin Yu, Shu-Ying Huang, Jing-Jing Xie, Xiu-Li Yang, Wen-Hang Li, Ying-Xing Zhang, Ge Zhang, Jing-Jia Duan, Si-Meng Kang, Wei Wang, Tong Li, Jin Xiao, Meng Hou, Xin Xu, Ying-Chun |
關鍵字: | Candida duobushaemulonii; FUR1; antifungal susceptibility; drug resistance mechanisms; whole genome sequence | 公開日期: | 2022 | 出版社: | FRONTIERS MEDIA SA | 卷: | 13 | 來源出版物: | Frontiers in microbiology | 摘要: | Candida duobushaemulonii, type II Candida haemulonii complex, is closely related to Candida auris and capable of causing invasive and non-invasive infections in humans. Eleven strains of C. duobushaemulonii were collected from China Hospital Invasive Fungal Surveillance Net (CHIF-NET) and identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), VITEK 2 Yeast Identification Card (YST), and internal transcribed spacer (ITS) sequencing. Whole genome sequencing of C. duobushaemulonii was done to determine their genotypes. Furthermore, C. duobushaemulonii strains were tested by Sensititre YeastOne™ and Clinical and Laboratory Institute (CLSI) broth microdilution panel for antifungal susceptibility. Three C. duobushaemulonii could not be identified by VITEK 2. All 11 isolates had high minimum inhibitory concentrations (MICs) to amphotericin B more than 2 μg/ml. One isolate showed a high MIC value of ≥64 μg/ml to 5-flucytosine. All isolates were wild type (WT) for triazoles and echinocandins. FUR1 variation may result in C. duobushaemulonii with high MIC to 5-flucytosine. Candida duobushaemulonii mainly infects patients with weakened immunity, and the amphotericin B resistance of these isolates might represent a challenge to clinical treatment. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/627953 | ISSN: | 1664-302X | DOI: | 10.3389/fmicb.2022.1001845 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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