https://scholars.lib.ntu.edu.tw/handle/123456789/628044
標題: | COVID-19 associated mold infections: Review of COVID-19 associated pulmonary aspergillosis and mucormycosis | 作者: | Huang, Shiang-Fen Ying-Jung Wu, Alice Shin-Jung Lee, Susan YU-SHAN HUANG Lee, Chun-Yuan Yang, Te-Liang Wang, Hsiao-Wei Chen, Hung Jui Chen, Yi Ching Ho, Tzong-Shiann Kuo, Chien-Feng Lin, Yi-Tsung |
關鍵字: | Aspergillosis; CAM; CAPA; COVID-19; Mucormycosis | 公開日期: | 2023 | 來源出版物: | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi | 摘要: | COVID-19-associated mold infection (CAMI) is defined as development of mold infections in COVID-19 patients. Co-pathogenesis of viral and fungal infections include the disruption of tissue barrier following SARS CoV-2 infection with the damage in the alveolar space, respiratory epithelium and endothelium injury and overwhelming inflammation and immune dysregulation during severe COVID-19. Other predisposing risk factors permissive to fungal infections during COVID-19 include the administration of immune modulators such as corticosteroids and IL-6 antagonist. COVID-19-associated pulmonary aspergillosis (CAPA) and COVID-19-associated mucormycosis (CAM) is increasingly reported during the COVID-19 pandemic. CAPA usually developed within the first month of COVID infection, and CAM frequently arose 10-15 days post diagnosis of COVID-19. Diagnosis is challenging and often indistinguishable during the cytokine storm in COVID-19, and several diagnostic criteria have been proposed. Development of CAPA and CAM is associated with a high mortality despiteappropriate anti-mold therapy. Both isavuconazole and amphotericin B can be used for treatment of CAPA and CAM; voriconazole is the primary agent for CAPA and posaconazole is an alternative for CAM. Aggressive surgery is recommended for CAM to improve patient survival. A high index of suspicion and timely and appropriate treatment is crucial to improve patient outcome. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628044 | ISSN: | 16841182 | DOI: | 10.1016/j.jmii.2022.12.004 |
顯示於: | 醫學系 |
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