A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia
Journal
British journal of haematology
Date Issued
2023-02-06
Author(s)
Wang, Yu-Hung
Gurashi, Kristian
Amaral, Fabio M R
Bossenbroek, Hasse
Jerez, Andres
Somervaille, Tim C P
Binder, Moritz
Patnaik, Mrinal M
Batta, Kiran
Wiseman, Daniel H
Abstract
Leukaemic stem cell (LSC) gene expression has recently been linked to prognosis in patients with acute myeloid leukaemia (17-gene LSC score, LSC-17) and myelodysplastic syndromes. Although chronic myelomonocytic leukaemia (CMML) is regarded as a stem cell disorder, the clinical and biological impact of LSCs on CMML patients remains elusive. Making use of multiple independent validation cohorts, we here describe a concise three-gene expression signature (LSC-3, derived from the LSC-17 score) as an independent and robust prognostic factor for leukaemia-free and overall survival in CMML. We propose that LSC-3 could be used to supplement existing risk stratification systems, to improve prognostic performance and guide management decisions.
Subjects
chronic myelomonocytic leukaemia; leukaemia stem cell; prognostic scoring system
SDGs
Type
journal article