https://scholars.lib.ntu.edu.tw/handle/123456789/628111
標題: | Role of Ketogenic Diets in Multiple Sclerosis and Related Animal Models: An Updated Review | 作者: | Lin, Wei-Sheng SHAN-JU LIN Liao, Pei-Yin Suresh, Divya Hsu, Ting-Rong Wang, Pei-Yu |
關鍵字: | decanoic acid; demyelination; experimental autoimmune encephalomyelitis; ketogenic diet; multiple sclerosis; neuroinflammation; β-hydroxybutyrate | 公開日期: | 九月-2022 | 出版社: | OXFORD UNIV PRESS | 卷: | 13 | 期: | 5 | 起(迄)頁: | 2002 | 來源出版物: | Advances in nutrition (Bethesda, Md.) | 摘要: | Prescribing a ketogenic diet (KD) is a century-old dietary intervention mainly used in the context of intractable epilepsy. The classic KD and its variants regained popularity in recent decades, and they are considered potentially beneficial in a variety of neurological conditions other than epilepsy. Many patients with multiple sclerosis (MS) have attempted diet modification for better control of their disease, although evidence thus far remains insufficient to recommend a specific diet for these patients. The results of 3 pilot clinical trials of KD therapy for MS, as well as several related studies, have been reported in recent years. The preliminary findings suggest that KD is safe, feasible, and potentially neuroprotective and disease-modifying for patients with MS. Research on corresponding rodent models has also lent support to the efficacy of KD in the prevention and treatment of experimental autoimmune encephalomyelitis and toxin-induced inflammatory demyelinating conditions in the brain. Furthermore, the animal studies have yielded mechanistic insights into the molecular mechanisms of KD action in relevant situations, paving the way for precision nutrition. Herein we review and synthesize recent advances and also identify unresolved issues, such as the roles of adipokines and gut microbiota, in this field. Hopefully this panoramic view of current understanding can inform future research directions and clinical practice with regard to KD in MS and related conditions. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628111 | ISSN: | 21618313 | DOI: | 10.1093/advances/nmac065 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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