https://scholars.lib.ntu.edu.tw/handle/123456789/628187
標題: | Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics | 作者: | Lee, Sheng-Han Du, Zhi-Yi Tseng, Wei-Chen WAN-YU LIN Chen, Mei-Huei CHINGCHUN LIN Liang, Hao-Jan Wen, Hui-Ju YUE-LIANG GUO PAU-CHUNG CHEN CHING-YU LIN |
關鍵字: | Children; Metabolomics; Nuclear magnetic resonance; Phthalate; Serum | 公開日期: | 1-一月-2023 | 出版社: | ELSEVIER SCI LTD | 卷: | 316 | 期: | Pt 1 | 來源出版物: | Environmental Pollution | 摘要: | Phthalates have become important environmental pollutants due to their high exposure frequency in daily life; thus, phthalates are prevalent in humans. Although several epidemiologic surveys have linked phthalates with several adverse health effects in humans, the molecular events underlying phthalate exposure have not been fully elucidated. The purpose of this study was to reveal associations between phthalate exposure and the serum metabolome in Taiwanese children using a metabolomic approach. A total of 256 Taiwanese children (8-10 years old) from two cohorts were enrolled in this study. Twelve urinary phthalate metabolites were analyzed by high-performance liquid chromatography/tandem mass spectrometry, while a nuclear magnetic resonance-based metabolomic approach was used to record serum metabolic profiles. The associations between metabolic profiles and phthalate levels were assessed by partial least squares analysis coupled with multiple linear regression analysis. Our results revealed that unique phthalate exposures, such as mono-isobutyl phthalate, mono-n-butyl phthalate, and mono (2-ethyl-5-oxohexyl) phthalate, were associated with distinct serum metabolite profiles. These phthalate-mediated metabolite changes may be associated with perturbed energy mechanisms, increased oxidative stress, and lipid metabolism. In conclusion, this study suggests that metabolomics is a valid approach to examine the effects of environmental-level phthalate on the serum metabolome. This study also highlighted potentially important phthalates and their possible effects on children. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628187 | ISSN: | 0269-7491 | DOI: | 10.1016/j.envpol.2022.120454 |
顯示於: | 環境與職業健康科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。