https://scholars.lib.ntu.edu.tw/handle/123456789/628279
標題: | Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trial | 作者: | JYH-MING LIOU Jiang, Xiao-Tao CHIEH-CHANG CHEN Luo, Jiing-Chyuan Bair, Ming-Jong Chen, Po-Yueh Chou, Chu-Kuang YU-JEN FANG MEI-JYH CHEN CHIEN-CHUAN CHEN Lee, Ji-Yuh Yang, Tsung-Hua Yu, Chien-Chun Kuo, Chia-Chi Chiu, Min-Chin Chen, Chi-Yi CHIA-TUNG SHUN Hu, Wen-Hao Tsai, Min-Horn Hsu, Yao-Chun Tseng, Cheng-Hao Chang, Chi-Yang JAW-TOWN LIN El-Omar, Emad M MING-SHIANG WU Wu, Chun-Ying Lee, Yi-Chia PING-HUEI TSENG Wu, Jeng-Yih Tai, Chi-Ming Lee, Ching-Tai Wang, Wen-Lun |
公開日期: | 三月-2023 | 卷: | 8 | 期: | 3 | 起(迄)頁: | 228 | 來源出版物: | The lancet. Gastroenterology & hepatology | 摘要: | Levofloxacin-based therapy or bismuth-based quadruple therapy are the recommended second-line regimens for Helicobacter pylori eradication after failure of clarithromycin-based therapy. However, resistance to levofloxacin has increased in the past decade. Furthermore, little is known about the long-term effects of H pylori eradication on the antibiotic resistome. In this study, we compared these second-line eradication therapies for efficacy, tolerability, and short-term and long-term effects on the gut microbiota, antibiotic resistome, and metabolic parameters. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628279 https://www.scopus.com/record/display.uri?eid=2-s2.0-85147659187&doi=10.1016%2fS2468-1253%2822%2900384-3&origin=inward&txGid=45f2e44263e75d8498b99bbd2ca746a8 |
ISSN: | 24681253 | DOI: | 10.1016/S2468-1253(22)00384-3 |
顯示於: | 法醫學科所 |
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