https://scholars.lib.ntu.edu.tw/handle/123456789/628777
標題: | Universal Infant Hepatitis B Virus (HBV) Vaccination for 35 Years: Moving Toward the Eradication of HBV | 作者: | KAI-CHI CHANG MEI-HWEI CHANG HUEY-LING CHEN JIA-FENG WU Chang, Chin-Hao HONG-YUAN HSU YEN-HSUAN NI |
關鍵字: | hepatitis B; mother-to-infant transmission; occult HBV infection; vaccination | 公開日期: | 1-二月-2022 | 出版社: | OXFORD UNIV PRESS INC | 卷: | 225 | 期: | 3 | 起(迄)頁: | 431 | 來源出版物: | The Journal of Infectious Diseases | 摘要: | A universal hepatitis B virus (HBV) vaccination program has been implemented in Taiwan since 1984. A total of 1611 individuals in Taipei were enrolled to monitor long-term efficacy. The prevalences of hepatitis B surface antigen (HBsAg) and hepatitis B core antibody in the vaccinated birth cohort were lower than in those born before 1984 (0.4% vs 7.7%, and 2.2% vs 50.8%, respectively; P < .0001). Three vaccine-failure carriers all were born to HBsAg-carrier mothers, probably due to no antiviral intervention during pregnancy. Occult HBV infection was rare in the postvaccination era. High vaccination coverage, comprehensive HBV screening, and antiviral agents for pregnant mothers will be essential to eliminate HBV transmission. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628777 | ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jiab401 |
顯示於: | 醫學教育暨生醫倫理學科所 |
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