https://scholars.lib.ntu.edu.tw/handle/123456789/628821
標題: | The ocular graft-versus-host disease: the path from current knowledge to future managements | 作者: | Chiang, Tung Lin Sun, Yi Chen Wu, Jo Hsuan Hsieh, Ying Tung Huang, Wei Lun WEI-LI CHEN |
關鍵字: | SEVERE DRY EYE; CONSENSUS DEVELOPMENT PROJECT; SUPERIOR LIMBIC KERATOCONJUNCTIVITIS; BONE-MARROW-TRANSPLANTATION; SPLEEN TYROSINE KINASE; NERVE GROWTH-FACTOR; AUTOLOGOUS SERUM; CLINICAL-TRIALS; CELL TRANSPLANTATION; TACROLIMUS OINTMENT | 公開日期: | 2023 | 出版社: | SPRINGERNATURE | 卷: | 37 | 期: | 10 | 起(迄)頁: | 1982 | 來源出版物: | Eye (Basingstoke) | 摘要: | Background: Graft-versus-host disease (GVHD) is one of the major complications of allogenic haematopoietic stem cell transplantation (HSCT). The manifestation of ocular GVHD (oGVHD) is variable and may involve cornea, lacrimal gland, conjunctiva, eyelid, and/or nasolacrimal duct. We reviewed and summarized the current managements of oGVHD with specific focus on the emerging therapeutic advances. Methods: PubMed, Web of Science, and Google Scholar were searched for relevant literatures published within 20 years. Keywords used included “Graft-Versus-Host Disease”, “GVHD”, “ocular”, “ocular surface”, “ocular GVHD”, “oGVHD”, “dry eye”, “keratitis”, etc. Results: Current managements of oGVHD can be classified into topical immunosuppressants, local tear-preservatory treatments, local non-pharmacological/surgical interventions, and systemic treatments. Additionally, some innovative therapies with promising treatment effects have been proposed, including topical target therapies, epitheliotrophic and neurotrophic treatments, recombinant DNase eye drops, mesenchymal stromal cell injection, and more. Conclusions: Clinical managements of oGVHD are administered in a symptom-based, stepwise manner. The advances in innovative therapies may help improve clinical outcomes, and it is essential that physicians stay updated with these novel treatment options. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628821 | ISSN: | 0950222X | DOI: | 10.1038/s41433-022-02288-9 |
顯示於: | 醫學系 |
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