https://scholars.lib.ntu.edu.tw/handle/123456789/628975
標題: | Distinct brain lipid signatures in response to low-level PM2.5 exposure in a 3xTg-Alzheimer's disease mouse inhalation model | 作者: | Lee, Sheng-Han CHING-YU LIN Chen, Ta-Fu Chou, Charles C-K Chiu, Ming-Jang Tee, Boon Lead Liang, Hao-Jan TSUN-JEN CHENG |
關鍵字: | Alzheimer's disease; Ambient fine particulate matter; Lipidomics; Neurotoxicity; Transgenic mouse model | 公開日期: | 10-九月-2022 | 出版社: | ELSEVIER | 卷: | 838 | 期: | Pt 4 | 來源出版物: | The Science of the Total Environment | 摘要: | Fine particulate matter (PM2.5) poses a significant risk to human health. The molecular mechanisms underlying low-level PM2.5-induced neurotoxicity in the central nervous system remain unclear. In addition, changes in lipids in response to PM2.5 exposure have not yet been fully elucidated. In this study, 3xTg-Alzheimer's disease (AD) mice experienced continuous whole-body exposure to non-concentrated PM2.5 for three consecutive months, while control mice inhaled particulate matter-filtered air over the same time span. A liquid chromatography-mass spectrometry-based lipidomic platform was used to determine the distinct lipid profiles of various brain regions. The average PM2.5 concentration during the exposure was 11.38 μg/m3, which was close to the regulation limits of USA and Taiwan. The partial least squares discriminant analysis model showed distinct lipid profiles in the cortex, hippocampus, and olfactory bulb, but not the cerebellum, of mice in the exposure group. Increased levels of fatty acyls, glycerolipids, and sterol lipids, as well as the decreased levels of glycerophospholipids and sphingolipids in PM2.5-exposed mouse brains may be responsible for the increased energy demand, membrane conformation, neuronal loss, antioxidation, myelin function, and cellular signaling pathways associated with AD development. Our research suggests that subchronic exposure to low levels of PM2.5 may cause neurotoxicity by changing the lipid profiles in a susceptible model. Lipidomics is a powerful tool to study the early effects of PM2.5-induced AD toxicity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/628975 | ISSN: | 0048-9697 | DOI: | 10.1016/j.scitotenv.2022.156456 |
顯示於: | 環境與職業健康科學研究所 |
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