https://scholars.lib.ntu.edu.tw/handle/123456789/629016
標題: | Invasive and Noninvasive Brain Stimulation in Parkinson's Disease: Clinical Effects and Future Perspectives | 作者: | KAI-HSIANG CHEN Chen, R. |
關鍵字: | TRANSCRANIAL MAGNETIC STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; SUPPLEMENTARY MOTOR AREA; THETA-BURST STIMULATION; HIGH-FREQUENCY STIMULATION; MEDICAL THERAPY; DOUBLE-BLIND; AFFERENT INHIBITION; CORTEX EXCITABILITY; COORDINATED RESET | 公開日期: | 2019 | 出版社: | WILEY | 卷: | 106 | 期: | 4 | 起(迄)頁: | 763 | 來源出版物: | Clinical Pharmacology and Therapeutics | 摘要: | In this review, we discuss the clinical and electrophysiological effects and the future directions of invasive and noninvasive brain stimulations in Parkinson's disease (PD). Deep brain stimulation (DBS) can improve motor symptoms in moderate to advanced PD. However, the optimal stimulation paradigm for nonmotor symptoms (NMS), freezing of gait, and the optimal timing of DBS are still under investigation. The findings of pathological oscillations and abnormal frequency to amplitude coupling provide models to develop adaptive DBS. Transcranial magnetic stimulation (TMS) revealed abnormal cortical excitability and plasticity in PD. Consecutive sessions of high-frequency, repetitive TMS on the motor cortex showed promising results. Paired TMS and DBS at specific times provided a novel way to investigate PD pathophysiology and have potential as a future treatment. Transcranial direct current stimulation or transcranial alternating current stimulation with multifocal electrodes or at specific phases of oscillation are also potential future strategies. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629016 | ISSN: | 0009-9236 1532-6535 |
DOI: | 10.1002/cpt.1542 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。