https://scholars.lib.ntu.edu.tw/handle/123456789/629059
標題: | Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities | 作者: | Liu, Cong Cai, Jing Chen, Renjie Sera, Francesco Guo, Yuming Tong, Shilu Li, Shanshan Lavigne, Eric Correa, Patricia Matus Ortega, Nicolas Valdes Orru, Hans Maasikmets, Marek Jaakkola, Jouni J K Ryti, Niilo Breitner, Susanne Schneider, Alexandra Katsouyanni, Klea Samoli, Evangelia Hashizume, Masahiro Honda, Yasushi Ng, Chris Fook Sheng Diaz, Magali Hurtado la Cruz Valencia, César De Rao, Shilpa Palomares, Alfonso Diz-Lois Pereira da Silva, Susana Madureira, Joana Holobâc, Iulian Horia Fratianni, Simona Scovronick, Noah Garland, Rebecca M Tobias, Aurelio Íñiguez, Carmen Forsberg, Bertil Åström, Christofer Vicedo-Cabrera, Ana Maria Ragettli, Martina S YUE-LIANG GUO Pan, Shih-Chun Milojevic, Ai Bell, Michelle L Zanobetti, Antonella Schwartz, Joel Gasparrini, Antonio Kan, Haidong |
關鍵字: | PM2.5-10; air pollution; mortality; multicenter study; time-series study | 公開日期: | 15-十月-2022 | 出版社: | AMER THORACIC SOC | 卷: | 206 | 期: | 8 | 起(迄)頁: | 999 | 來源出版物: | American journal of respiratory and critical care medicine | 摘要: | Rationale: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality are not fully understood on a global scale. Objectives: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. Methods: We collected daily mortality (total, cardiovascular, and respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine PM. A two-stage time-series analytic approach was applied, with overdispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from copollutants (fine PM, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled, and regional analyses were conducted. Measurements and Main Results: A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI], 0.18%-0.84%), 0.43% (95% CI, 0.15%-0.71%), and 0.41% (95% CI, 0.06%-0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all copollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. Conclusions: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular, and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629059 | ISSN: | 1073-449X | DOI: | 10.1164/rccm.202111-2657OC |
顯示於: | 環境與職業健康科學研究所 |
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