https://scholars.lib.ntu.edu.tw/handle/123456789/629084
標題: | Highly Efficient Singlet Oxygen Generation by BODIPY-Ruthenium(II) Complexes for Promoting Neurite Outgrowth and Suppressing Tau Protein Aggregation | 作者: | Wu, Cheng-Yun Chen, Hsin-Jou Wu, Yun-Chin Tsai, Shu-Wei Liu, Yi-Hung Bhattacharya, Ushashi Lin, Duo Tai, Hwan-Ching KIEN-VOON KONG |
關鍵字: | NERVE GROWTH-FACTOR; PHOTODYNAMIC THERAPY; ALZHEIMERS-DISEASE; IN-VITRO; PEPTIDE AGGREGATION; NADPH OXIDASE; AMYLOID-BETA; RUTHENIUM; BODIPY; DISSOCIATION | 公開日期: | 23-一月-2023 | 出版社: | AMER CHEMICAL SOC | 卷: | 62 | 期: | 3 | 起(迄)頁: | 1102 | 來源出版物: | Inorganic chemistry | 摘要: | Singlet oxygen (1O2) has been recently identified as a key molecule against toxic Aβ aggregation, which is associated with the currently incurable Alzheimer's disease (AD). However, limited research has studied its efficiency against tau protein aggregation, the other major hallmark of AD. Herein, we designed and synthesized boron-dipyrromethene (BODIPY)-ruthenium conjugates and isolated three isomers. Under visible-light irradiation, the ε isomer can be photoactivated and efficiently generate singlet oxygen. Particularly, the complex demonstrated successful results in attenuating tauopathy─an appreciable decrease to 43 ± 2% at 100 nM. The photosensitizer was further found to remarkably promote neurite outgrowth and significantly increased the length and number of neurites in nerve cells. As a result of effective photoinduced singlet oxygen generation and proactive neurite outgrowth, the hybrid design has great potential for therapeutics for Alzheimer's disease. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629084 | ISSN: | 0020-1669 | DOI: | 10.1021/acs.inorgchem.2c03017 |
顯示於: | 化學系 |
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