Highly Efficient Singlet Oxygen Generation by BODIPY-Ruthenium(II) Complexes for Promoting Neurite Outgrowth and Suppressing Tau Protein Aggregation
Journal
Inorganic chemistry
Journal Volume
62
Journal Issue
3
Pages
1102
Date Issued
2023-01-23
Author(s)
Wu, Cheng-Yun
Chen, Hsin-Jou
Wu, Yun-Chin
Tsai, Shu-Wei
Liu, Yi-Hung
Bhattacharya, Ushashi
Lin, Duo
Tai, Hwan-Ching
Abstract
Singlet oxygen (1O2) has been recently identified as a key molecule against toxic Aβ aggregation, which is associated with the currently incurable Alzheimer's disease (AD). However, limited research has studied its efficiency against tau protein aggregation, the other major hallmark of AD. Herein, we designed and synthesized boron-dipyrromethene (BODIPY)-ruthenium conjugates and isolated three isomers. Under visible-light irradiation, the ε isomer can be photoactivated and efficiently generate singlet oxygen. Particularly, the complex demonstrated successful results in attenuating tauopathy─an appreciable decrease to 43 ± 2% at 100 nM. The photosensitizer was further found to remarkably promote neurite outgrowth and significantly increased the length and number of neurites in nerve cells. As a result of effective photoinduced singlet oxygen generation and proactive neurite outgrowth, the hybrid design has great potential for therapeutics for Alzheimer's disease.
Subjects
NERVE GROWTH-FACTOR; PHOTODYNAMIC THERAPY; ALZHEIMERS-DISEASE; IN-VITRO; PEPTIDE AGGREGATION; NADPH OXIDASE; AMYLOID-BETA; RUTHENIUM; BODIPY; DISSOCIATION
SDGs
Publisher
AMER CHEMICAL SOC
Type
journal article