https://scholars.lib.ntu.edu.tw/handle/123456789/629086
標題: | The inhibition in tumor necrosis factor-alpha-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-kappaB and reactive oxygen species | 作者: | Lin, Pen-Yuan Shen, Hsi-Che Chen, Chien-Jen Wu, Shu-En HSIEN-LI KAO Huang, Jen-Hung Wang, Danny Ling Chen, Shih-Chung |
關鍵字: | Carvedilol; Endothelial cell; Reactive oxygen species; Thrombomodulin; Tumor necrosis factor; CHRONIC HEART-FAILURE; BETA-ADRENOCEPTOR ANTAGONIST; CELL-ADHESION MOLECULE-1; FREE-RADICAL SCAVENGER; IN-VITRO; OXIDATIVE STRESS; ANTIHYPERTENSIVE AGENT; EJECTION FRACTION; ANTIOXIDANT; METOPROLOL | 公開日期: | 一月-2010 | 出版社: | SPRINGER | 卷: | 29 | 期: | 1 | 起(迄)頁: | 52 | 來源出版物: | Journal of thrombosis and thrombolysis | 摘要: | Carvedilol, a nonselective beta-adrenoceptor antagonist, has been shown to possess antioxidant effects and reduce the risk of hospitalization and death in patients with severe congestive heart failure, which is featured by the activation of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), and leads to thrombotic complications. Thrombomodulin (TM) plays protective roles against thrombosis. Treatment of ECs with TNF-alpha resulted in a down-regulation in the TM expression in a time-dependent manner. Pre-treatment of ECs with carvedilol (1 and 10 microM) for 1 h significantly up-regulated the TM expression in ECs in response to TNF-alpha. When ECs were pre-treated with a nuclear factor-kappaB (NF-kappaB) inhibitor, i.e., parthenolide, their TNF-alpha-mediated down-regulation of TM expression was inhibited. Pre-treatment of ECs with carvedilol inhibited the NF-kappaB-DNA binding activity in ECs induced by TNF-alpha. Our findings provide insights into the mechanisms by which carvedilol exerts anti-thrombotic effects by inducing TM expression in ECs in response to pro-inflammatory stimulation. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629086 https://www.scopus.com/record/display.uri?eid=2-s2.0-77949913053&doi=10.1007%2fs11239-009-0318-2&origin=inward&txGid=6162bdfbd3fae6f7e9d7ca9e9e9689ee |
ISSN: | 0929-5305 | DOI: | 10.1007/s11239-009-0318-2 |
顯示於: | 醫學系 |
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