https://scholars.lib.ntu.edu.tw/handle/123456789/629456
標題: | Chemoprevention of oral cancer: A review and future perspectives | 作者: | Liao, Yu Hao Chou, Wei Yi Chang, Chun Wei MEI-CHUN LIN CHENG-PING WANG PEI-JEN LOU TSENG-CHENG CHEN |
關鍵字: | chemoprevention | leukoplakia | oral cancer | oral potentially malignant disorders | second primary tumor | 公開日期: | 1-一月-2023 | 出版社: | WILEY | 卷: | 45 | 期: | 4 | 來源出版物: | Head and Neck | 摘要: | Background: Oral cancer causes significant morbidity and mortality. Chemoprevention utilizes medication or natural compounds to reverse oral premalignant lesions and to prevent second primary tumors. Methods: A comprehensive PubMed database and Cochrane Library search from 1980 to 2021 was performed using the keywords “leukoplakia,” “oral premalignant lesion,” and “chemoprevention.”. Results: Chemopreventive agents included retinoids, carotenoids, cyclooxygenase inhibitor, herbal extracts, bleomycin, tyrosine kinase inhibitors, metformin, and immune checkpoint inhibitors. Although some agents demonstrated effect in reducing premalignant lesions and preventing second primary tumors, the results among different studies were highly variable. Conclusions: The results of different trials, albeit inconsistent, provided substantial information for future studies. In the era of personalized medicine, future studies will focus on identifying specific biomarkers and molecular profile to monitor and to prevent malignant transformation. Larger trials are warranted to validate the effect of chemopreventive agents. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629456 | ISSN: | 10433074 | DOI: | 10.1002/hed.27301 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。