Epstein-barr virus-based nasopharyngeal carcinoma (NPC) risk prediction scores are elevated in NPC multiplex family members in Taiwan
Journal
Journal of Infectious Diseases
Journal Volume
223
Journal Issue
3
Pages
441
Date Issued
2021-02-01
Author(s)
Lee, Mei Hsuan
Coghill, Anna E.
Liu, Zhiwei
Yu, Kelly J.
Hsu, Wan Lun
Chien, Yin Chu
Chen, Chien Jen
Hildesheim, Allan
Abstract
Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control.
Subjects
genetic susceptibility | host-virus interactions | immune | multiplex antibody array | virus control
SDGs
Publisher
OXFORD UNIV PRESS INC
Type
journal article