https://scholars.lib.ntu.edu.tw/handle/123456789/629500
標題: | Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h | 作者: | Lee, Kuan-Yi Liu, Chia-Ming Chen, Li-Han Lee, Chien-Yueh TZU-PIN LU Chuang, Li-Ling LIANG-CHUAN LAI |
關鍵字: | Breast cancer; Hypoxia; Radiosensitivity; Tumor suppressor; circAAGAB; miRNA sponge; p38 MAPK | 公開日期: | 10-三月-2023 | 出版社: | BioMed Central Ltd | 卷: | 23 | 期: | 1 | 來源出版物: | Cancer cell international | 摘要: | Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629500 | ISSN: | 1475-2867 | DOI: | 10.1186/s12935-023-02891-0 |
顯示於: | 流行病學與預防醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。