Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h
Journal
Cancer cell international
Journal Volume
23
Journal Issue
1
ISSN
1475-2867
Date Issued
2023-03-10
Author(s)
Abstract
Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and treatment resistance. Recently, accumulating evidence indicates that non-coding RNAs, such as circular RNAs (circRNAs), play a pivotal role in altering cellular functions. However, the underlying mechanisms of circRNAs in breast cancer are still unclear. Therefore, the purpose of this study was to investigate the role of a tumor-suppressive circRNA, circAAGAB, in breast cancer by assuming down-regulation of circAAGAB under hypoxia and the properties of a tumor suppressor.
Subjects
Breast cancer
Hypoxia
Radiosensitivity
Tumor suppressor
circAAGAB
miRNA sponge
p38 MAPK
SDGs
Publisher
BioMed Central Ltd
Type
journal article