https://scholars.lib.ntu.edu.tw/handle/123456789/629502
標題: | End-Stage Renal Disease Patients Undergoing Hemodialysis Have Higher Possibility of Return of Spontaneous Circulation during Out-of-Hospital Cardiac Arrest and Non-Inferior Short-Term Survival | 作者: | Hsieh, Ming-Shun Chattopadhyay, Amrita TZU-PIN LU Liao, Shu-Hui Chang, Chia-Ming Lee, Yi-Chen Lo, Wei-En Wu, Jia-Jun Hsieh, Vivian Chia-Rong Hu, Sung-Yuan How, Chorng-Kuang |
關鍵字: | acidosis; cardiopulmonary resuscitation (CPR); end-stage renal disease (ESRD); hyperkalemia; out-of-hospital cardiac arrest (OHCA); return of spontaneous circulation (ROSC) | 公開日期: | 6-十一月-2022 | 出版社: | MDPI | 卷: | 11 | 期: | 21 | 來源出版物: | Journal of clinical medicine | 摘要: | End-stage renal disease (ESRD) patients on long-term hemodialysis (HD) have an elevated risk of sudden cardiac death. This study hypothesizes, for the first time, that these patients have a higher odds of return of spontaneous circulation (ROSC) and subsequent better hospital-outcomes, post out-of-hospital cardiac arrest (OHCA), as opposed to non-ESRD patients. A national database from Taiwan was utilized, in which 101,876 ESRD patients undergoing HD and propensity score-matched non-ESRD patients were used to conduct two analyses: (i) Cox-proportional-hazards-regression for OHCA incidence and (ii) logistic-regression analysis of attaining ROSC after OHCA, both for ESRD patients in comparison to non-ESRD patients. Kaplan-Meier analyses were conducted to determine the difference of survival rates after ROSC between the two cohorts. ESRD patients were found to be at a higher risk of OHCA (adjusted-HR = 2.11, 95% CI: (1.89−2.36), p < 0.001); however, they were at higher odds of attaining ROSC (adjusted-OR = 2.47, 95% CI: 1.90−3.21, p < 0.001), as opposed to non-ESRDs. Further, Kaplan-Meier analysis demonstrated ESRD patients with a better 30-day hospital survival rate than non-ESRD patients. Although ESRD patients had a higher risk of OHCA, they demonstrated higher possibility of ROSC and a better short-term hospital outcome than non-ESRDs. Chronic toxin tolerance and the training of vascular-compliance during regular HD may be possible explanations for better outcomes in ESRD patients. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629502 | ISSN: | 2077-0383 | DOI: | 10.3390/jcm11216582 |
顯示於: | 流行病學與預防醫學研究所 |
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