https://scholars.lib.ntu.edu.tw/handle/123456789/629526
標題: | Posterior Reversible Encephalopathy Syndrome after Lenvatinib Therapy in a Patient with Olfactory Neuroblastoma | 作者: | Tseng, Yu-Ju CHUN-NAN CHEN RUEY-LONG HONG Kung, Woon-Man ABEL PO-HAO HUANG |
關鍵字: | lenvatinib; olfactory neuroblastoma; posterior reversible encephalopathy syndrome | 公開日期: | 23-一月-2023 | 出版社: | MDPI | 卷: | 13 | 期: | 1 | 來源出版物: | Brain sciences | 摘要: | Posterior reversible encephalopathy syndrome (PRES) is a rare but severe neurological syndrome that may stem from the use of some medications. Although its mechanism is not well-known, hypertension and endothelial dysfunction have been mentioned in previous literature as being related. Lenvatinib serves as a neoplastic agent that inhibits the tyrosine kinase of vascular endothelial growth factor receptors (VEGFR). VEGFR inhibitors result in endothelial dysfunction and consequent hypertension by nitric oxide pathway suppression and endothelin (ET)-1 stimulation. We hypothesized that VEGFR inhibitors would cause PRES. Herein, we report the case of a 40-year-old man with olfactory neuroblastoma who developed PRES while undergoing treatment with lenvatinib, 7 months after initiation. The symptoms included loss of consciousness and seizures. Fortunately, the symptoms and presence of PRES in imaging resolved, 7 days and 1 month, respectively, after cessation of lenvatinib. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629526 | ISSN: | 2076-3425 | DOI: | 10.3390/brainsci13010033 |
顯示於: | 醫學系 |
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