https://scholars.lib.ntu.edu.tw/handle/123456789/629614
標題: | Piceatannol and 3'-Hydroxypterostilbene Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice | 作者: | Lin, Wei-Sheng Chueh, Tai-Ling Nagabhushanam, Kalyanam Ho, Chi-Tang MIN-HSIUNG PAN |
關鍵字: | 3′-hydroxypterostilbene; NLRP3 inflammasome; colitis; piceatannol; tight junctions | 公開日期: | 1-二月-2023 | 出版社: | AMER CHEMICAL SOC | 卷: | 71 | 期: | 4 | 來源出版物: | Journal of agricultural and food chemistry | 摘要: | Inflammatory bowel disease has become a significant health concern across the globe, causing frequent and long-term harm to the digestive system. This study evaluated the effect of piceatannol (PIC) and 3'-hydroxypterostilbene (HPSB) on dextran sulfate sodium (DSS)-induced colitis in mice and investigated whether their effects are exerted through the amelioration of gut barrier dysfunction to reduce the severity of colitis. The findings showed that both PIC and HPSB attenuated inflammation by inhibiting the TNF-α/NF-κB/MLC pathway and reducing NLRP3 inflammasome activation. However, PIC was comparably effective in modulating tight junctions. The results may be attributed to the effect of PIC on reducing cell apoptosis-associated protein expression, including Bax/Bcl-2 and caspase-3 activation. Furthermore, microbiota analysis revealed that both PIC and HPSB increased representative probiotic species, including Akkermansiaceae and Lactobacillus intestinalis, and exhibited inhibitory effects on several bacterial species (Spiroplasmataceae and Acholeplasmataceae). Based on linear discriminant analysis effect size, butyrate-producing bacteria were identified as a biomarker in the PIC group. Overall, the results demonstrated that PIC repressed inflammation, inhibited cell apoptosis, and regulated microbiota composition. Consequently, PIC is more effective in maintaining gut barrier integrity than HPSB, and it is a promising ingredient in the development of functional food for colitis prevention. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/629614 | ISSN: | 0021-8561 | DOI: | 10.1021/acs.jafc.2c08170 |
顯示於: | 食品科技研究所 |
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