Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count
Journal
JAMA psychiatry
Journal Volume
78
Journal Issue
12
Pages
1365
Date Issued
2021-12-01
Author(s)
Sealock, Julia M
Lee, Younga H
Moscati, Arden
Venkatesh, Sanan
Voloudakis, Georgios
Straub, Peter
Singh, Kritika
Ge, Tian
Roussos, Panos
Smoller, Jordan W
Chen, Guanhua
Davis, Lea K
Abstract
Although depression is a common psychiatric disorder, its underlying biological basis remains poorly understood. Pairing depression polygenic scores with the results of clinical laboratory tests can reveal biological processes involved in depression etiology and in the physiological changes resulting from depression.
Subjects
C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; NEUTROPHIL-LYMPHOCYTE; GROWTH-FACTOR; STRESS; NEUROINFLAMMATION; INFLAMMATION; ACTIVATION; MICROGLIA; CYTOKINES
SDGs
Publisher
AMER MEDICAL ASSOC
Type
journal article