https://scholars.lib.ntu.edu.tw/handle/123456789/630118
標題: | Molecularly Imprinted Polymer/Anodic Aluminum Oxide Nanocomposite Sensing Electrode for Low-Concentration Troponin T Detection for Patient Monitoring Applications | 作者: | YU-TSAN LIN Wang, Liang-Kai Cheng, Yu-Ting CHIH-KUO LEE Tsai, Hsiao-En |
關鍵字: | anodic aluminum oxide;cardiac troponin T;limit of detection;molecularly imprinted polymer;nanocomposite electrode;reusability;specificity | 公開日期: | 25-六月-2021 | 出版社: | AMER CHEMICAL SOC | 卷: | 6 | 期: | 6 | 起(迄)頁: | 2429 | 來源出版物: | ACS sensors | 摘要: | Various clinical studies have shown that myocardial troponin T (cTnT) is highly correlated with acute myocardial infarction (AMI). A highly sensitive molecularly imprinted polymer (MIP) sensing electrode for the detection of cTnT in patients' blood serum can enable cost-effective, rapid, and real-time testing for patients requiring intensive care. However, the existing MIP-based sensing electrode does not perform well for low-concentration detection of cTnT (<0.2 ng/mL). In this study, a new type of sensing electrode, an anodic aluminum oxide molecularly imprinted (MIP/AAO) nanocomposite electrode is developed. By incorporating the AAO structure, i.e., one-dimensional (1D) pillars, through a semiconductor-compatible process, the new electrode exhibits a great performance improvement, higher sensitivity of 1.08 × 10-4 and 4.25 × 10-4 in the low (<0.03 ng/mL)- and high-concentration regions, respectively, and a lower limit of detection (LoD) of 5.34 pg/mL. Because the composite electrode can maintain a linear characteristic in the measurement range of low-concentration cTnT, it can effectively improve the accuracy and reduce the error in cTnT measurement. In addition, the novel sensing electrode exhibits good reusability and specificity. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630118 | ISSN: | 2379-3694 | DOI: | 10.1021/acssensors.1c00738 |
顯示於: | 醫學系 |
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