A Brief Review of Graphene-Based Biosensors Developed for Rapid Detection of COVID-19 Biomarkers
Journal
Biosensors
Journal Volume
13
Journal Issue
3
Date Issued
2023-03-01
Author(s)
Chandrasekar, Narendhar
Balaji, Ramachandran
Perala, Ramaswamy Sandeep
Nik Humaidi, Nik Zulkarnine
Shanmugam, Kirubanandan
Hwang, Michael Taeyoung
Govindaraju, Saravanan
Abstract
The prevalence of mutated species of COVID-19 antigens has provided a strong impetus for identifying a cost-effective, rapid and facile strategy for identifying the viral loads in public places. The ever-changing genetic make-up of SARS-CoV-2 posts a significant challenfge for the research community to identify a robust mechanism to target, bind and confirm the presence of a viral load before it spreads. Synthetic DNA constructs are a novel strategy to design complementary DNA sequences specific for antigens of interest as in this review’s case SARS-CoV-2 antigens. Small molecules, complementary DNA and protein–DNA complexes have been known to target analytes in minimal concentrations. This phenomenon can be exploited by nanomaterials which have unique electronic properties such as ballistic conduction. Graphene is one such candidate for designing a device with a very low LOD in the order of zeptomolar and attomolar concentrations. Surface modification will be the significant aspect of the device which needs to have a high degree of sensitivity at the same time as providing a rapid signaling mechanism.
Subjects
antigens | complementary DNA | COVID-19 | protein–DNA | SARS
Publisher
MDPI
Type
other