https://scholars.lib.ntu.edu.tw/handle/123456789/630244
標題: | Antiobesity and hypolipidemic effects of protease A-digested crude-chalaza hydrolysates in a high-fat diet | 作者: | Chen, Jr Wei Lin, Yi Ling CHUNG-HSI CHOU Wu, Yi Hsieng Samuel SHENG-YAO WANG YI-CHEN CHEN |
關鍵字: | Crude chalaza hydrolysates; Fecal lipid/bile-acid output; Lipid metabolism; Obesity; Serum antioxidant level; Serum lipid | 公開日期: | 1-三月-2020 | 出版社: | ELSEVIER | 卷: | 66 | 來源出版物: | Journal of Functional Foods | 摘要: | A high-fat diet is a major risk factor for obesity and heart failure. Our previous study has demonstrated that protease A-digested crude-chalaza hydrolysates (CCH-As) with a specific free amino-acid and carnosine/anserine profile show lipid-lowering and antioxidant activities against chronic alcohol consumption. The antiobesity and hypolipidemic effects of our CCH-As against a high-fat diet was to investigated in this study. In high-fat-diet fed hamsters, supplementing CCH-As reduced liver/perirenal-adipose-tissue sizes, and serum triglyceride, LDLC/HDLC, and TBARS values (p < 0.05). Supplementing CCH-As increased lipolysis (hormone sensitive lipase, carnitine palmitoyltransferase 1, and uncoupling protein 2) in the perirenal-adipose tissues of high-fat-diet fed hamsters (p < 0.05); meanwhile decreased cholesterol biosynthesis (squalene synthase), and upregulated bile-acid biosynthesis (cholesterol 7 alpha-hydroxylase) and cholesterol clearance ability (low-density lipoprotein receptor) in livers (p < 0.05). Daily fecal lipid and bile-acid outputs were also increased in high-fat-diet fed hamsters cotreated with CCH-As. Therefore, this CCH-A can be characterized as an antiobesity and cardioprotective ingredient. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078580970&doi=10.1016%2fj.jff.2020.103788&partnerID=40&md5=7ec4ed96a16f34f87867abf8b0a1da6c https://scholars.lib.ntu.edu.tw/handle/123456789/630244 |
ISSN: | 17564646 | DOI: | 10.1016/j.jff.2020.103788 |
顯示於: | 動物科學技術學系 |
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