https://scholars.lib.ntu.edu.tw/handle/123456789/630592
標題: | Sub-lethal concentration of sulfamethoxazole affects the growth performance of milkfish (Chanos chanos), the microbial composition of antibiotic-resistant bacteria and the prevalence of sulfonamide-resistance genes in mariculture | 作者: | Lau, Sai Hung JIH-TAY HSU Chen, Yu jie Li, Ze Fong Chao, Wei Liang Yeh, Shinn Lih Ying, Chingwen |
關鍵字: | Antibiotic resistance | Bacterial composition | Marine aquaculture | Milkfish farming | sul gene | Sulfamethoxazole | 公開日期: | 1-九月-2022 | 出版社: | PERGAMON-ELSEVIER SCIENCE LTD | 卷: | 182 | 來源出版物: | Marine Pollution Bulletin | 摘要: | To investigate the impacts of sub-lethal concentrations of antibiotic agents in mariculture, culturable approach and DNA based detection were employed to isolate and analyse resistant bacteria and resistant genes in this study. Milkfish (Chanos chanos), the target rearing animal was exposed to sulfamethoxazole (SMX; 2 mg/L) for 8 weeks and resulted in reduced survival rate and weight gain to 61.9 % and 28.4 %, respectively compared to control milkfish (p < 0.001). The composition of SMX-resistant bacteria isolated from the culture water and the gastrointestinal tracts of milkfish underwent changes in response to SMX treatment with a reduced diversity. The prevalence of SMX resistant genes sul in bacterial isolates was elevated from 2.8 % of control to 100 % of SMX-administrated water. Exposure to SMX at a sub-lethal dosage enhanced the prevalence of resistance genes sul1 and sul2 in resistant bacteria, thus implying high frequency of resistance dissemination in the marine environment and surrounding ecosystems. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135769300&doi=10.1016%2fj.marpolbul.2022.113989&partnerID=40&md5=345cd079431b35cc0a8f4095a554b482 https://scholars.lib.ntu.edu.tw/handle/123456789/630592 |
ISSN: | 0025326X | DOI: | 10.1016/j.marpolbul.2022.113989 |
顯示於: | 動物科學技術學系 |
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