https://scholars.lib.ntu.edu.tw/handle/123456789/630621
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Zhou, Daming | en_US |
dc.contributor.author | Duyvesteyn, Helen M.E. | en_US |
dc.contributor.author | Chen, Cheng Pin | en_US |
dc.contributor.author | Huang, Chung Guei | en_US |
dc.contributor.author | Chen, Ting Hua | en_US |
dc.contributor.author | Shih, Shin Ru | en_US |
dc.contributor.author | Lin, Yi Chun | en_US |
dc.contributor.author | Cheng, Chien Yu | en_US |
dc.contributor.author | Cheng, Shu Hsing | en_US |
dc.contributor.author | Huang, Yhu Chering | en_US |
dc.contributor.author | Lin, Tzou Yien | en_US |
dc.contributor.author | Ma, Che | en_US |
dc.contributor.author | Huo, Jiandong | en_US |
dc.contributor.author | Carrique, Loic | en_US |
dc.contributor.author | Malinauskas, Tomas | en_US |
dc.contributor.author | Ruza, Reinis R. | en_US |
dc.contributor.author | Shah, Pranav N.M. | en_US |
dc.contributor.author | Tan, Tiong Kit | en_US |
dc.contributor.author | Rijal, Pramila | en_US |
dc.contributor.author | Donat, Robert F. | en_US |
dc.contributor.author | Godwin, Kerry | en_US |
dc.contributor.author | Buttigieg, Karen R. | en_US |
dc.contributor.author | Tree, Julia A. | en_US |
dc.contributor.author | Radecke, Julika | en_US |
dc.contributor.author | Paterson, Neil G. | en_US |
dc.contributor.author | Supasa, Piyada | en_US |
dc.contributor.author | Mongkolsapaya, Juthathip | en_US |
dc.contributor.author | Screaton, Gavin R. | en_US |
dc.contributor.author | Carroll, Miles W. | en_US |
dc.contributor.author | Gilbert-Jaramillo, Javier | en_US |
dc.contributor.author | Knight, Michael L. | en_US |
dc.contributor.author | James, William | en_US |
dc.contributor.author | Owens, Raymond J. | en_US |
dc.contributor.author | Naismith, James H. | en_US |
dc.contributor.author | Townsend, Alain R. | en_US |
dc.contributor.author | Fry, Elizabeth E. | en_US |
dc.contributor.author | Zhao, Yuguang | en_US |
dc.contributor.author | Ren, Jingshan | en_US |
dc.contributor.author | Stuart, David I. | en_US |
dc.contributor.author | Kuan-Ying A. Huang | en_US |
dc.date.accessioned | 2023-04-26T01:46:48Z | - |
dc.date.available | 2023-04-26T01:46:48Z | - |
dc.date.issued | 2020-10-01 | - |
dc.identifier.issn | 15459993 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/630621 | - |
dc.description.abstract | The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A, from an individual convalescing from COVID-19 and have shown that it neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1. EY6A Fab binds the receptor binding domain (RBD) of the viral spike glycoprotein tightly (KD of 2 nM), and a 2.6-Å-resolution crystal structure of an RBD–EY6A Fab complex identifies the highly conserved epitope, away from the ACE2 receptor binding site. Residues within this footprint are key to stabilizing the pre-fusion spike. Cryo-EM analyses of the pre-fusion spike incubated with EY6A Fab reveal a complex of the intact spike trimer with three Fabs bound and two further multimeric forms comprising the destabilized spike attached to Fab. EY6A binds what is probably a major neutralizing epitope, making it a candidate therapeutic for COVID-19. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | Nature Structural and Molecular Biology | en_US |
dc.subject | NANOLITRE CRYSTALLIZATION EXPERIMENTS; CRYO-EM STRUCTURE; SARS CORONAVIRUS; POTENT NEUTRALIZATION; PROTEIN; SPIKE | en_US |
dc.title | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41594-020-0480-y | - |
dc.identifier.pmid | 32737466 | - |
dc.identifier.scopus | 2-s2.0-85088842557 | - |
dc.identifier.isi | WOS:000559353900001 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85088842557 | - |
dc.relation.pages | 950 | en_US |
dc.relation.journalvolume | 27 | en_US |
dc.relation.journalissue | 10 | en_US |
dc.relation.pageend | 958 | en_US |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Immunology | - |
crisitem.author.orcid | 0000-0001-6891-6945 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 免疫學研究所 |
檔案 | 描述 | 大小 | 格式 | |
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s41594-020-0480-y.pdf | Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient | 8.95 MB | Adobe PDF | 檢視/開啟 |
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