https://scholars.lib.ntu.edu.tw/handle/123456789/630630
標題: | Anti-Quenching NIR-II J-Aggregates of Benzo[c]thiophene Fluorophore for Highly Efficient Bioimaging and Phototheranostics | 作者: | Lee, Ka-Wai Gao, Yijian Wei, Wei-Chih Tan, Ji-Hua Wan, Yingpeng Feng, Zhe Zhang, Yuhuang Liu, Ying Zheng, Xiuli Cao, Chen Chen, Huan Wang, Pengfei Li, Shengliang KEN-TSUNG WONG Lee, Chun-Sing |
關鍵字: | J-aggregates; NIR-II fluorescence imaging; aggregation-induced emission; large Stokes shift; molecular fluorophores; phototheranostics | 公開日期: | 3-三月-2023 | 出版社: | WILEY-V C H VERLAG GMBH | 來源出版物: | Advanced materials (Deerfield Beach, Fla.) | 摘要: | Molecular fluorophores with the second near-infrared (NIR-II) emission hold great potential for deep-tissue bioimaging owing to their excellent biocompatibility and high resolution. Recently, J-aggregates are used to construct long-wavelength NIR-II emitters as their optical bands show remarkable red shifts upon forming water-dispersible nano-aggregates. However, their wide applications in the NIR-II fluorescence imaging are impeded by the limited varieties of J-type backbone and serious fluorescence quenching. Herein, a bright benzo[c]thiophene (BT) J-aggregate fluorophore (BT6) with anti-quenching effect is reported for highly efficient NIR-II bioimaging and phototheranostics. The BT fluorophores are manipulated to have Stokes shift over 400 nm and aggregation-induced emission (AIE) property for conquering the self-quenching issue of the J-type fluorophores. Upon forming BT6 assemblies in an aqueous environment, the absorption over 800 nm and NIR-II emission over 1000 nm are boosted for more than 41 and 26 folds, respectively. In vivo visualization of the whole-body blood vessel and imaging-guided phototherapy results verify that BT6 NPs are excellent agent for NIR-II fluorescence imaging and cancer phototheranostics. This work develops a strategy to construct bright NIR-II J-aggregates with precisely manipulated anti-quenching properties for highly efficient biomedical applications. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630630 | ISSN: | 0935-9648 | DOI: | 10.1002/adma.202211632 |
顯示於: | 化學系 |
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