https://scholars.lib.ntu.edu.tw/handle/123456789/630744
標題: | Decoronation-induced infected alveolar socket defect rat model for ridge preservation | 作者: | Fang, Chih-Hsiang Lin, Hung-Ying Sun, Chung-Kai Lin, Yi-Wen Hung, Min-Chih Li, Ching-Hung Lin, I-Ping Chang, Hung-Chen Sun, Jui-Sheng JENNY ZWEI-CHIENG CHANG |
關鍵字: | EXTRACTION SOCKETS; BIO-OSS(R) COLLAGEN; DIMENSIONAL CHANGES; TOOTH EXTRACTION; BONE SUBSTITUTE; ANIMAL-MODELS; REGENERATION; OUTCOMES; CONTOUR | 公開日期: | 15-六月-2022 | 出版社: | NATURE PORTFOLIO | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Current rat alveolar ridge preservation models have not been well standardized. In this study, we proposed decoronation-induced infected alveolar socket model of rat. The bilateral maxillary first molars (M1) of twenty-four rats were decoronized or extracted. After 2, 6, 10, and 14 weeks, bone and soft tissue changes at M1 and periodontal conditions of maxillary second (M2) and third molars (M3) were evaluated by micro-computed tomography and histological analysis. Additional eighteen rats with standardized size defects were grafted with Bio-Oss Collagen to compare with unmanipulated contralateral side. Decoronation preserved greater bone and soft tissue dimensions at M1, provided larger three-dimensional (3D) bone contour volume, but also promoted periodontal breakdown of M2 Histological results showed intense inflammatory cell infiltrations and severe bone resorption within M1 socket and at mesial aspect of M2. The critical dimensions to accommodate largest standardized defect at M1 were 2.2-2.3 mm at vertical bone height and 2.8-3.2 mm at alveolar crestal width. Bio-Oss Collagen could not fully preserve buccal or palatal bone height but could be beneficial in preserving ridge width in large alveolar defects. Collectively, if periodontally-involved alveolar bone defect is preferred, we suggest extracting M1 roots 6 weeks after decoronation to allow periodontitis to occur at M2. If standardized critical dimension defect is preferred, we suggest extracting M1 roots 2 weeks after decoronation, and creating defect in the middle of M1 site with size no larger than 2.7 mm diameter to its full depth. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630744 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-14064-6 |
顯示於: | 牙醫學系 |
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