https://scholars.lib.ntu.edu.tw/handle/123456789/630830
標題: | Antiproliferation Effects of Marine-Sponge-Derived Methanol Extract of Theonella swinhoei in Oral Cancer Cells In Vitro | 作者: | Shiau, Jun-Ping Chuang, Ya-Ting Tang, Jen-Yang Chen, Shu-Rong Hou, Ming-Feng JIIANG-HUEI JENG Cheng, Yuan-Bin Chang, Hsueh-Wei |
關鍵字: | marine sponge; natural product; oral cancer; oxidative stress | 公開日期: | 4-十月-2022 | 出版社: | MDPI | 卷: | 11 | 期: | 10 | 來源出版物: | Antioxidants (Basel, Switzerland) | 摘要: | The purpose of this study aimed to assess the antiproliferation effects of methanol extract of T. swinhoei (METS) and explore the detailed responses of oral cancer cells compared to normal cells. METS effectively inhibits the cell proliferation of oral cancer cells but does not affect normal cell viability, exhibiting preferential antiproliferation function. METS exerted more subG1 accumulation, apoptosis induction, cellular and mitochondrial oxidative stress, and DNA damage than normal cells, reverted by oxidative stress inhibitor N-acetylcysteine. This METS-caused oxidative stress was validated to attribute to the downregulation of glutathione. METS activated both extrinsic and intrinsic caspases. DNA double-strand breaks (γH2AX) and oxidative DNA damage (8-hydroxy-2-deoxyguanosine) were stimulated by METS. Therefore, for the first time, this investigation shed light on exploring the functions and responses of preferential antiproliferation of METS in oral cancer cells. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630830 | ISSN: | 2076-3921 | DOI: | 10.3390/antiox11101982 |
顯示於: | 臨床牙醫學研究所 |
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