https://scholars.lib.ntu.edu.tw/handle/123456789/630845
標題: | Synergistic Antiproliferation of Cisplatin and Nitrated [6,6,6]Tricycle Derivative (SK2) for a Combined Treatment of Oral Cancer Cells | 作者: | Wang, Sheng-Chieh Yen, Ching-Yu Shiau, Jun-Ping Chang, Meng-Yang Hou, Ming-Feng JIIANG-HUEI JENG Tang, Jen-Yang Chang, Hsueh-Wei |
關鍵字: | antiproliferation; combined treatment; nitrated [6,6,6]tricycles; oral cancer | 公開日期: | 8-五月-2022 | 出版社: | MDPI | 卷: | 11 | 期: | 5 | 來源出版物: | Antioxidants (Basel, Switzerland) | 摘要: | SK2, a nitrated [6,6,6]tricycle derivative with an n-butyloxy group, showed selective antiproliferation effects on oral cancer but not on normal oral cells. This investigation assessed for the first time the synergistic antiproliferation potential of cisplatin/SK2 in oral cancer cells. Cell viability assay at 24 h showed that a low dose of combined cisplatin/SK2 (10 μM/10 μg/mL) provided more antiproliferation than cisplatin or SK2 alone. Cisplatin/SK2 triggered also more apoptosis inductions in terms of subG1 accumulation, annexin V, pancaspase, and caspase 3/8/9 measurements. Moreover, cisplatin/SK2 provided more oxidative stress and DNA damage in oral cancer cells than independent treatments. Oxidative stress inhibitors rescued the cisplatin/SK2-induced antiproliferation and oxidative stress generation. Moreover, cisplatin/SK2 induced more antiproliferation, apoptosis, oxidative stress, and DNA damage in oral cancer cells than in normal oral cells (S-G). In conclusion, low-dose cisplatin/SK2 combined treatment promoted selective and synergistic antiproliferation in oral cancer cells depending on oxidative-stress-associated responses. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/630845 | ISSN: | 2076-3921 | DOI: | 10.3390/antiox11050926 |
顯示於: | 臨床牙醫學研究所 |
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