https://scholars.lib.ntu.edu.tw/handle/123456789/631013
標題: | IFN-stimulated metabolite transporter ENT3 facilitates viral genome release | 作者: | Hsieh, Yu-Ting Tsai, Tsung-Lin Huang, Shen-Yan Heng, Jian-Wen Huang, Yu-Chia Tsai, Pei-Yuan Tu, Chia-Chun TAI-LING CHAO Tsai, Ya-Min Chang, Pei-Ching CHIEN-KUO LEE Yu, Guann-Yi SUI-YUAN CHANG Dzhagalov, Ivan L Hsu, Chia-Lin |
關鍵字: | equilibrative nucleoside transporter; interferon-stimulated gene; macrophage; metabolite transporter; viral replication | 公開日期: | 6-三月-2023 | 出版社: | WILEY | 卷: | 24 | 期: | 3 | 來源出版物: | EMBO Reports | 摘要: | An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Suprisingly, we unveil that several viruses, including SARS-CoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631013 | ISSN: | 1469-221X | DOI: | 10.15252/embr.202255286 |
顯示於: | 免疫學研究所 |
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