https://scholars.lib.ntu.edu.tw/handle/123456789/631036
標題: | Exposure of Immunogenic Tumor Antigens in Surrendered Immunity and the Significance of Autologous Tumor Cell-Based Vaccination in Precision Medicine | 作者: | Ke, Chiao Hsu Chiu, Yi Han KUO-CHIN HUANG CHEN-SI LIN |
關鍵字: | autologous cancer vaccine; immunoediting; immunogenicity; precision medicine; tumor antigens | 公開日期: | 1-一月-2023 | 出版社: | MDPI | 卷: | 24 | 期: | 1 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | The mechanisms by which immune systems identify and destroy tumors, known as immunosurveillance, have been discussed for decades. However, several factors that lead to tumor persistence and escape from the attack of immune cells in a normal immune system have been found. In the process known as immunoediting, tumors decrease their immunogenicity and evade immunosurveillance. Furthermore, tumors exploit factors such as regulatory T cells, myeloid-derived suppressive cells, and inhibitory cytokines that avoid cytotoxic T cell (CTL) recognition. Current immunotherapies targeting tumors and their surroundings have been proposed. One such immunotherapy is autologous cancer vaccines (ACVs), which are characterized by enriched tumor antigens that can escalate specific CTL responses. Unfortunately, ACVs usually fail to activate desirable therapeutic effects, and the low immunogenicity of ACVs still needs to be elucidated. This difficulty highlights the significance of immunogenic antigens in antitumor therapies. Previous studies have shown that defective host immunity triggers tumor development by reprogramming tumor antigenic expressions. This phenomenon sheds new light on ACVs and provides a potential cue to improve the effectiveness of ACVs. Furthermore, synergistically with the ACV treatment, combinational therapy, which can reverse the suppressive tumor microenvironments, has also been widely proposed. Thus, in this review, we focus on tumor immunogenicity sculpted by the immune systems and discuss the significance and application of restructuring tumor antigens in precision medicine. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145966650&doi=10.3390%2fijms24010147&partnerID=40&md5=cee9fbef12bc3860ca90feaef3fa6a95 https://scholars.lib.ntu.edu.tw/handle/123456789/631036 |
ISSN: | 16616596 | DOI: | 10.3390/ijms24010147 | SDG/關鍵字: | human; immunotherapy; neoplasm; personalized medicine; tumor microenvironment; vaccination |
顯示於: | 獸醫學系 |
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