https://scholars.lib.ntu.edu.tw/handle/123456789/631042
標題: | Changes in gene expression profiles and cytokine secretions in peripheral monocytes by treatment with small extracellular vesicles derived from a canine lymphoma cell line | 作者: | Tani, Akiyoshi Tomiyasu, Hirotaka Asada, Hajime CHEN-SI LIN Goto-Koshino, Yuko Ohno, Koichi Tsujimoto, Hajime |
關鍵字: | diffuse large B-cell lymphoma; dog; monocyte chemotactic protein-1; nuclear factor-kappa β signaling; toll-like receptor signaling | 公開日期: | 1-一月-2022 | 出版社: | JAPAN SOC VET SCI | 卷: | 84 | 期: | 5 | 起(迄)頁: | 712 | 來源出版物: | Journal of Veterinary Medical Science | 摘要: | Interactions between tumor and immune cells within the tumor microenvironment play an important role in tumor progression, and small extracellular vesicles (EVs) derived from these tumor cells have been shown to exert immunomodulatory effects on various immune cells, including macrophages and lymphocytes. Although the immunomodulatory effects of small EVs derived from human cancer cells have been intensively investigated, few studies have investigated the effects of lymphoma-derived small EVs on macrophages in both human and veterinary medicine. Here, we evaluated the effects of canine lymphoma-derived small EVs on canine primary monocytes, which are the major source of macrophages in neoplastic tissues. Comprehensive gene expression analysis of these treated monocytes revealed their distinct activation via the Toll-like receptor (TLR) and NF-κβ signaling pathways. In addition, treatment with lymphoma small EVs increased the secretion of MCP-1, which induces the infiltration and migration of monocytes and lymphocytes in neoplastic and cancer tissues. The results of this study indicate that canine lymphoma small EVs activate monocytes, possibly through the activation of TLR and NF-κβ signaling pathways, and induce monocytes to secrete of MCP-1, which might contribute to immune cell infiltration within the tumor microenvironment. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131107365&doi=10.1292%2fjvms.21-0506&partnerID=40&md5=8442335cca3b315f5d336812a1b3f1b0 https://scholars.lib.ntu.edu.tw/handle/123456789/631042 |
ISSN: | 09167250 | DOI: | 10.1292/jvms.21-0506 |
顯示於: | 獸醫學系 |
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