Lycium chinense Polysaccharide Suppressed Hypertrophy and Hyperplasia in Adipocytes through Regulating Lipid and Glucose Metabolism
Journal
ACS Food Science and Technology
Journal Volume
1
Journal Issue
6
Pages
1014
Date Issued
2021-07-16
Author(s)
Chung, Chia Jung
Chuang, Yu Chang
Wu, Yi Shin
Lin, Han Huei
Hung, Peng Yun
Lin, Yu Ling
Liao, Kuang Wen
Abstract
Obesity is a major public health issue, and it is often associated with metabolic abnormalities. Lycium chinense Mill. polysaccharide (LCP) is considered to have antiobesity potential due to its hypoglycemic and hypolipidemic effects. However, the mechanisms associated with its antiobesity effects are still not well understood. In this study, LCP not only inhibited the size and number of lipid droplets but also led to cell death in 3T3-L1 adipocytes through downregulating cyclin D1 expression. LCP effectively decreased body weight in high-fat diet (HFD)-induced obese mice. LCP also decelerated the white adipose tissue (WAT) formation in obese mice and improved their hepatic steatosis. LCP might inhibit fatty acid synthesis and improve β-oxidation and glycolysis by modulating the gene expression of key enzymes of lipogenesis and glycolysis in adipocytes. Therefore, LCP may have antihypertrophy and antiproliferative effects and be used as a daily supplement for weight control.
Subjects
cyclin D1; lipid droplet accumulation; Lycium chinense polysaccharides (LCP); obesity
SDGs
Publisher
AMER CHEMICAL SOC
Type
journal article