https://scholars.lib.ntu.edu.tw/handle/123456789/631044
標題: | Lycium chinense Polysaccharide Suppressed Hypertrophy and Hyperplasia in Adipocytes through Regulating Lipid and Glucose Metabolism | 作者: | Chung, Chia Jung Chuang, Yu Chang CHEN-SI LIN Wu, Yi Shin Lin, Han Huei Hung, Peng Yun Lin, Yu Ling Liao, Kuang Wen |
關鍵字: | cyclin D1; lipid droplet accumulation; Lycium chinense polysaccharides (LCP); obesity | 公開日期: | 16-七月-2021 | 出版社: | AMER CHEMICAL SOC | 卷: | 1 | 期: | 6 | 起(迄)頁: | 1014 | 來源出版物: | ACS Food Science and Technology | 摘要: | Obesity is a major public health issue, and it is often associated with metabolic abnormalities. Lycium chinense Mill. polysaccharide (LCP) is considered to have antiobesity potential due to its hypoglycemic and hypolipidemic effects. However, the mechanisms associated with its antiobesity effects are still not well understood. In this study, LCP not only inhibited the size and number of lipid droplets but also led to cell death in 3T3-L1 adipocytes through downregulating cyclin D1 expression. LCP effectively decreased body weight in high-fat diet (HFD)-induced obese mice. LCP also decelerated the white adipose tissue (WAT) formation in obese mice and improved their hepatic steatosis. LCP might inhibit fatty acid synthesis and improve β-oxidation and glycolysis by modulating the gene expression of key enzymes of lipogenesis and glycolysis in adipocytes. Therefore, LCP may have antihypertrophy and antiproliferative effects and be used as a daily supplement for weight control. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127174179&doi=10.1021%2facsfoodscitech.1c00046&partnerID=40&md5=2384e0b613652c20eaf8891cb912fc56 https://scholars.lib.ntu.edu.tw/handle/123456789/631044 |
ISSN: | 2692-1944 | DOI: | 10.1021/acsfoodscitech.1c00046 |
顯示於: | 獸醫學系 |
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