High-throughput screening of chemical libraries for modulators of gene promoter activity of HLA-B2705: environmental pathogenesis and therapeutics of ankylosing spondylitis
Journal
The Journal of rheumatology
Journal Volume
38
Journal Issue
6
Pages
1061
Date Issued
2011-06
Author(s)
Abstract
Ankylosing spondylitis (AS) is a highly heritable disease with HLA-B27 being the strongest susceptible gene. In order to survey the environmental triggers for arthritis development, we used a high-throughput technique to screen the effects of 12,264 chemicals on the HLA-B27 gene promoter.
Subjects
ANKYLOSING SPONDYLITIS; FLAVONOID; LEI GONG TENG; NATURAL PRODUCTS; ENVIRONMENTAL PATHOGENESIS; WILFORDII HOOK-F; NF-KAPPA-B; RHEUMATOID-ARTHRITIS; NUCLEAR-FACTOR; DOUBLE-BLIND; RED-CLOVER; FLAVONOIDS; CHEMISTRY; INHIBITION; APIGENIN
Publisher
J RHEUMATOL PUBL CO
Type
journal article