https://scholars.lib.ntu.edu.tw/handle/123456789/631696
標題: | CRP-level-associated polymorphism rs1205 within the CRP gene is associated with 2-hour glucose level: The SAPPHIRe study | 作者: | Sheu, Wayne Huey-Herng Wang, Wen-Chang KWAN-DUN WU He, Chih-Tsueng Hwu, Chii-Min Quertermous, Thomas Hsieh, Wan-Shan Lee, Wen-Jane Ting, Chih-Tai Chen, Yii-Der I Hsiung, Chao A |
關鍵字: | C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; BLOOD-PRESSURE; LOAD GLUCOSE; PROMOTER; RISK; DISEASE; INTERLEUKIN-6; DETERMINANTS | 公開日期: | 11-八月-2017 | 出版社: | NATURE PUBLISHING GROUP | 卷: | 7 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | C-reactive protein (CRP) encoded by CRP gene is a reflection of systemic inflammation. Many studies associated CRP level with diabetes and glucose levels, but the association of CRP gene with these traits is unclear. We conducted a cross-sectional study consisting of 945 siblings from 330 families collected by the Stanford Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) to investigate associations between CRP polymorphisms, circulating CRP, diabetes, and glucose levels. Five single-nucleotide polymorphisms were analyzed: rs3093059, rs2794521, rs1417938, rs1800947, and rs1205. The generalized estimating equation approach was used to deal with correlated data within families. CRP level was positively correlated with diabetes prevalence and levels of fasting and 2-hour glucose (each P < 0.008). Alleles C at rs3093059 and G at rs1205 were associated with elevated CRP level (each P < 1.2 × 10-6). Allele C at rs3093059 was associated with fasting glucose (β = 0.20, P = 0.045) and G at rs1205 was associated with 2-hour glucose (β = 0.46, P = 0.00090) post oral glucose tolerance test, but only the latter passed Bonferroni correction. No polymorphism was associated with diabetes. Since 2-hour glucose is an indicator of glucose tolerance, this study indicated CRP gene is associated with glucose intolerance. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/631696 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-017-08696-2 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。